GROWTH FACTORS
Stem Cell Science For the Skin and Hair
The aging of skin is a known cellular degenerative process resulting from genetics and environmental factors (i.e. sun damage, air pollutants, etc.). The dermal layer of skin contains the structural elements and proteins necessary for maintaining skin thickness, elasticity, and vitality. With age, the rate of production of these proteins decreases, and results in wrinkling, laxity, dryness, and general thinning of the skin. Prominent wrinkling is caused by the loss of dermal collagen content, and a decreased rate of collagen production. With age, skin loses around 1% of its fibroblast population and thickness per year. The rate of decline in fibroblast cell number and function is increased by sun exposure, and recent
studies Have also shown that sun damaged skin has 35% fewer capillaries than normal skin.
Cellular cytokines and growth factors are known to be involved in a number of critical cellular processes including cell proliferation, adhesion, morphologic appearance, differentiation, migration, inflammatory responses, angiogenesis, and cell death. Studies have demonstrated that hypoxic stress and injury to skin cells induce responses including increased levels of mRNA, proteins, and corresponding growth factors such as PDGF, VEGF, FGF, and IGF. TGF-B expression is also induced during wound healing and has been shown to increase the expression of extracellular matrix proteins including collagen and fibronectin, and to accelerate the healing of wounds. PDGF is known to be a potent mitogen for MSCs, and increases the rate of cellularity and granulation in tissue formation through increased fibroblast function. Both PDGF and TGF-B have been shown to increase collagen formation, DNA content, and protein levels in animal studies. In general, it is thought desirable in the treatment of wounds and aging skin to enhance the supply of growth factors by direct addition of these factors. Thus through the application of AmaCell anti-aging skin serum, we seek to re-establish the natural environment of nascent skin by delivering critical structural proteins and relevant human growth factors directly to the skin.
The hair follicle is a sophisticated receptacle within the scalp from which hair grows by a process described as protein & carbohydrate synthesis. As one of the most active cellular parts of your body, the follicle is extremely sensitive to internal & external changes. Daily hair loss is normal, however when daily hair loss amounts are greater than the new hair growth, you should take immediate steps to correct this condition because thinning hair will soon be a fact of life.
What Are Stem Cells?
There are 2 basic types of stem cells - embryonic & adult. While controversy surrounds the use of embryonic stem cells, no such debate exists with the use of adult stem cells, which are naturally occurring in the body. All stem cells are capable of dividing & renewing themselves for long periods of time, & they can give rise to specialized cells. According to the National Institute of Health, stem cells have the remarkable potential to develop into many different cell types. When a stem cell divides, each new cell has the potential to either remain a stem cell or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell, a skin cell, etc. Serving as a repair system for the body, stem cells can theoretically divide without limit to replenish other cells.
The hair follicle is a tiny organ that contains stem cells that can regenerate it. At the base of the follicle is the hair bulb, where wildly growing matrix cells become hair. A little farther up the follicle is the mysterious feature called the bulge. That's where follicle stem cells live. hen they get the right set of chemical signals, these self-renewing cells divide. They don't divide like normal cells, in which both halves become new cells that keep splitting & developing. Only one half of the follicle stem cell does that. The other half becomes a new stem cell, & stays put for future regeneration.
ProGenix FC formula promotes healing via an interaction with the stem cell populations found in the hair follicle while also protecting existing stem cells from the harmful effects of free radicals; this is especially important because during the natural aging process, adult stem cells are known to have a reduced regenerative capacity, leaving cells more vulnerable to oxidative stress.
ProGenix FC-Follicle Rejuvenation Complex is a pharmaceutical grade all-natural stem cell proliferation product formulated with multiple human growth factors & matrix proteins that repair & rejuvenate damaged hair follicles to help minimize further signs of thinning hair while restoring its natural luminosity & health. ProGenix FC serum is formulated with the latest in
patent-pending tissue-engineering technology to deliver an unprecedented nine key growth factors found in human skin along with other proteins that support dermal integrity to rejuvenate damaged hair follicles. These natural human growth factors include TGF-b(1-3) [Transforming growth factor beta], PDGF [Platelet derived growth factor], GM-CSF [Granulocyte-macrophage colony-stimulating factor], & Interleukins (IL3, IL6-8). As we age, the production of these growth factors within the skin & hair follicle is reduced, leading to the thinning & brittle unhealthy texture of the hair.
By re-introducing these factors through daily application of ProGenix FC, damaged hair ollicles show drastic signs of improvement & repair. The visible results from the new regenerated follicles show that the re-emerging hair is thicker, stronger & more pigmented. moderate follicle renewal may occur within 5 to 6 weeks, but optimal improvement is generally reached after 3 months of daily use.
ProGenix FC is a topical formula & must be applied at least once a day to the affected area of the scalp & the surrounding areas. You must avoid washing your hair for at least three hours so the active ingredients can effectively get absorbed into your scalp. ProGenix FC can be applied at any time during the day but most people prefer to use it at night before going to bed.
